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Diabetic ketoacidosis and hyperglycemic hyperosmolar state
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Greiner has developed a hypothesis that the function of GLP-1 in the small intestine is to improve insulin secretion postprandially, whereas the functions of GLP-1 in the colon are to allow for increased energy intake (in a situation of energy deficiency), dampen inflammation, and protect local tissues
In previous studies, orforglipron reduced body weight by 12.4% and improved cardiometabolic risk factors after 72 weeks in adults with obesity without diabetes
This dual effect helps regulate blood glucose levels without causing significant hypoglycemia, as the insulin response diminishes when blood sugar normalizes
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